Introduction
Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin. Psilocin is the pharmacologically active agent in the body after ingestion of psilocybin or some species of psychedelic mushrooms.
Psilocybin is rapidly dephosphorylated in the body to psilocin which acts as a 5-HT2A, 5-HT2C and 5-HT1A agonist or partial agonist. Psilocin exhibits functional selectivity in that it activates phospholipase A2 instead of activating phospholipase C as the endogenous ligand serotonin does. Psilocin is structurally similar to serotonin (5-HT), differing only by the hydroxyl group being on the 4-position rather than the 5 and the dimethyl groups on the nitrogen. Its effects are thought to come from its agonist activity at 5-HT2A serotonin receptors in the prefrontal cortex.
Research PROGRAM
Awakened Biotech has an ongoing research program carried out by Prof. Durst at the University of Ottowa.
Contract in place
Ongoing intellectual property development
All intellectual property owned by Awakened Biotech
Low cost development
Access to world class labs and state of the art equipment
Employing students
Intellectual Property
Awakened Biotech has 3 provisional patents:
“app. 43337214”
“app. 43337167”
“app. 43337185”
that protect our proprietary psilocybin-making process
1
App. 43337214: Large-Scale Production of Psilocin and/or Psilocybin
This invention describes the production of psilocin and/or psilocybin. Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin. Psilocin is the pharmacologically active agent in the body after ingestion of psilocybin or some species of psychedelic mushrooms. This invention also relates to the production of intermediates, including but not limited to psilocin, different polymorphic forms of psilocybin, including isostructural variants, and their formulation for use in medicine.
2
App. 43337167: Large-Scale Production of Psilocin Analogs
Another invention also relates to the production of intermediates, including but not limited to psilocin, different polymorphic forms of psilocybin, including isostructural variants, and their formulation for use in medicine.
This invention describes the production of psilocin analogs. Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin. Psilocin is the pharmacologically active agent in the body after ingestion of psilocybin or some species of psychedelic mushrooms. Psilocybin is rapidly dephosphorylated in the body to psilocin which acts as a 5-HT2A, 5-HT2C and 5-HT1A agonist or partial agonist. Psilocin exhibits functional selectivity in that it activates phospholipase A2 instead of activating phospholipase C as the endogenous ligand serotonin does. Psilocin is structurally similar to serotonin (5-HT), differing only by the hydroxyl group being on the 4-position rather than the 5 and the dimethyl groups on the nitrogen. Its effects are thought to come from its agonist activity at 5-HT2A serotonin receptors in the prefrontal cortex. This invention also relates to the production of intermediates, including but not limited to psilocin, different polymorphic forms of psilocybin, including isostructural variants, and their formulation for use in medicine.
3
App. 43337185: Large-Scale Production of Psilocin and/or Psilocybin
The third invention describes the large-scale production of psilocin and/or psilocybin. It relates to a method of obtaining high purity crystalline compounds. It further relates to a method for the manufacture of psilocin/psilocybin and intermediates in the production thereof.
- This invention describes the production of psilocin and/or psilocybin. Psilocin (also known as 4-HO-DMT, 4-hydroxy DMT, psilocine, psilocyn, or psilotsin) is a substituted tryptamine alkaloid and a serotonergic psychedelic substance. It is present in most psychedelic mushrooms together with its phosphorylated counterpart psilocybin. Psilocin is the pharmacologically active agent in the body after ingestion of psilocybin or some species of psychedelic mushrooms. This invention also relates to the production of intermediates, including but not limited to psilocin, different polymorphic forms of psilocybin, including isostructural variants, and their formulation for use in medicine.
Awakened:
TWO ENDS OF THE SPECTRUM
Development of a novel approach to the extraction of psychedelic compounds
All natural API from natural mushrooms
POTENTIAL PRODUCTS
Entourage material added to known psilocybin doses
Dosed products for wellness clinics, based on section 56 exemption
Patents for synthesis of psilocybin
GMP-produced API
POTENTIAL PRODUCTS
API for clinical trials (psychedelic cos)
API for in-vitro and in-vivo studies (CROs)
